Berberine: Gukoresha, Inyungu, Inyongera n'ingaruka Zuruhande

Berberine ifite amateka maremare yo gukoresha muri sisitemu yubuvuzi gakondo, nkaAyurvedan'ubuvuzi bwa Aziya y'Uburasirazuba. Nibintu bivangwa nuburozi bikomoka ku bimera bitandukanye, nka hydrastis canadensis (goldenseal), coptis chinensis (coptis cyangwa goldenthread) na berberis vulgaris (barberry). Ubushakashatsi bwerekana ko berberine ishobora kugira imiti igabanya ubukana bwa antibiyotike na antibiyotike, kimwe n'ingaruka nziza kuri metabolism, ariko hakenewe ubundi bushakashatsi bwo kwa muganga kugira ngo hemezwe izo nyungu.

Berberine irashobora kandi kugira inyungu nyinshi za physiologique nibikorwa bya farumasi mu mwijima, impyiko, umutima n'ubwonko, birashobora gutanga izindi nkunga ya metabolike. Kurugero, berberine ikora enzyme AMP ikora protein kinase ikora ubushakashatsi, ubushakashatsi bwerekana ko bufasha kugenzura metabolism, imikorere ya selile nurwego rwingufu.

Berberine ikoreshwa cyane cyane mubishobora gufashagabanya isukari mu maraso, kuzamura ubuzima bwumutima nimiyoboro y'amaraso, kugabanya okiside itera kandicholesterol yo hasiHeather Zwickey, impamyabumenyi y'ikirenga, umwarimu w’ubudahangarwa muri kaminuza nkuru y’ubuvuzi karemano i Portland, Oregon, avuga ko, kimwe n’ingaruka zayo zo kurwanya impiswi, kurwanya indwara no kurwanya kanseri.

Berberine isanzwe iboneka muburyo bwa capsule, ariko kandi ikorwa nkigitonyanga cyamaso hamwe na geles kubintu bitandukanye bitera uruhu, amaso cyangwa ingingo.

Ibimera nimboga byinshi birimo berberine byakoreshejwe mubuvuzi mumyaka ibihumbi, nyamara birakenewe ubushakashatsi bwinshi kugirango dusobanukirwe nuburyo uruganda rukora ningaruka ndende. Hamwe n'ibimaze kuvugwa, ubushakashatsi bwerekana ko bushobora kugirira akamaro ubuzima bwawe muburyo butandukanye.

Irashobora Gufasha Isukari Yamaraso Hasi no Kurinda Kurwanya Insuline

Isubiramo rya 2022 muriMolekileyerekana berberine irashobora gufashagabanya glucosekuko byongera umusaruro wa insuline kandi bikanonosora insuline, nubwo hakenewe ubushakashatsi bwinshi kugirango twumve neza izo ngaruka[1].

Ashobora gufasha Cholesterol yo hepfo

Ubushakashatsi bwerekana berberine ishobora kugira ingaruka nziza kuriLDL cholesterolna cholesterol yuzuye, nubwo hakenewe ubundi bushakashatsi bwamavuriro kugirango twumve neza iki kibazo cyubuzima.

Irashobora Gutezimbere Ubuzima bwumutima

Berberine irashobora kugira ingaruka nziza kumitsi yumutima, cyane cyane mugihe cya ischemia (gutanga amaraso adahagije), mugutezimbere imbaraga zimitsi yumutima, kugabanya umuriro, kugabanya stress ya okiside, kugabanya umuvuduko wamaraso no kongera umutima.

Birashobora kugira Ingaruka zo Kurwanya

Aberia McCubbins, umuganga wa naturopathique ufite icyicaro i Vancouver, i Washington, avuga ko Berberine ari alkaloide isharira itanga ingaruka zifatika zo kurwanya indwara. Iyi mico irashobora kugirira akamaro muri metabolike muri rusange, nkibishobora kugira uruhare mukurinda aterosklerose, diyabete yo mu bwoko bwa 2, umubyibuho ukabije hamwe ningaruka z'umutima. Imiterere ya Berberine yo kurwanya inflammatory yakozwe ku burebure, ariko uburyo bwibikorwa byayo ntibirasobanuka, byerekana ko hakenewe ubundi bushakashatsi.

Ashobora kugira Antioxydeant

Isubiramo rya 2018 muriImipaka muri Farumasiasoza avuga ko antioxydeant ya berberine igereranywa na vitamine C, antioxydants ikomeye cyane[2]. Ibintu nka vitamine C na berberine bikora nka antioxydants kugirango bifashe kwirinda kwangirika kwa radicals yubusa bishobora gutera selile.

Hashobora Kugira Antibacterial na Antimicrobial Properties

Dr. McCubbins asangira agira ati: “Berberine ifite imiterere ikomeye kandi ifatwa nka mikorobe isanzwe ifite ubushobozi bwo kwirukana bagiteri, parasite na fungi / candida.” Iyi miti igabanya ubukana irashobora gufasha kunoza ibintu bimwe na bimwe, nka acuteimpiswi, dysentery, jaundice n'indwara zandurira mu nda ibyara, nubwo hakenewe ubushakashatsi bwinshi kugirango dushyigikire ibi birego. Niba umuntu ku giti cye yemera ko yanduye bagiteri ubwoko ubwo aribwo bwose, bagomba kubaza abashinzwe ubuzima kugira ngo basuzume neza kandi bavurwe mbere yo gufata berberine cyangwa ikindi kintu icyo ari cyo cyose.

Irashobora Gutezimbere Ubuzima bwigifu

Berberine irashobora kugirira akamaro ibibazo byigifu, nko kuribwa mu nda nagutwikank'uko byatangajwe na Dr. McCubbins. Yongeyeho ati: "Iyi alkaloide irashobora gutanga inyungu zitanga inyungu mu guhuza ubwonko n'ubwonko". Yashimangiye akamaro ko guhuza igogorwa, igifu ndetse n'ubuzima muri rusange.

Turashobora Gushyigikira Gutakaza Ibiro no gucunga ibiro

Ubushakashatsi bwerekana ko Berberine ishobora gufasha kugabanya ibinure na glucose mu kunoza imikorere ya metabolike, nko kumeneka kwa lipide (amavuta) hamwe nisukari. Ingaruka nziza ya Berberines kuri microbiome yo munda irashobora kandi kuba ikintu cyingenzi mugushigikira gucunga ibiro.

Ashobora Kunoza Ibimenyetso bya Syndrome ya Polycystic Ovarian (PCOS) na Ovulation

Ukurikije isubiramo muriMolekile, gufata miligarama 1.500 za berberine kumunsi mumezi atatu byagabanije urugero rwa testosterone nyinshi kubagore bafitePCOS[3]. Iyi miterere irashobora kuba irimo imisemburo yimyororokere idasanzwe kandi bikavamo ubusumbane butandukanye, biganisha kubibazo nka cysts nto kuri ovaries cyangwa imihango idasanzwe. Abahanga bemeza kandi ko berberine itezimbere insuline, ikaba ari ibintu bisanzwe biranga PCOS. Abashakashatsi bavuga ariko ko hakenewe ubundi bushakashatsi bw’amavuriro kugira ngo hemezwe ingaruka za berberine, harimo uburebure bwo kuvura hamwe no kuvura imiti.

 

Nigute ushobora gufata Berberine?

Berberine yinyongera iraboneka muri capsule, tablet cyangwa form ya tincure, ituma ikoreshwa neza kandi ikoreshwa neza. Dr. McCubbins asobanura ko Capsules ishobora kuba nziza kubakoresha benshi bitewe nuburyohe bwayo bukabije. “Berberine ikunze gufatwa nka tonic igogora iminota 5 kugeza 30 mbere yo kurya. Berberine isanzwe isharira itera imitobe yo mu gifu kugirango igogorwa ryiza rikore neza ".

Berberine

Dr. Zwickey avuga ko abantu ku giti cyabo bagomba kugisha inama abashinzwe ubuzima cyangwa abashinzwe ibyatsi kugira ngo baganire ku kunywa neza (bitari bisanzwe), kandi basome amabwiriza yabakozwe. “Muri rusange bifatwa nk'umutekano muri dosiye [ya buri munsi] ya garama 2. Kugirango [ugere ku bisubizo byiza], umuntu ku giti cye ashobora kuba ashaka gukoresha byibuze garama 1 (miligarama 1000) kumunsi. Ibyinshi mu byongeweho [birimo] miligarama 500 kuri capsule, ku buryo umuntu yashaka gufata [byibuze bibiri] ku munsi, ”akomeza.

Igipimo cya Berberine gishobora guterwa nintego zubuzima bwumuntu. Kubyerekeye isukari yamaraso, isubiramo rifatika rya 2019 hamwe na meta-isesengura muriIkinyamakuru Endocrinewasanze gufata munsi ya garama 2 za berberine kumunsi mumezi atatu byagize ingaruka nziza kumaraso glucose yabitabiriye bafite diyabete yo mu bwoko bwa 2[4].

Hagati aho, gusubiramo ubushakashatsi buboneka muriUbuvuzi Bwuzuye Mubikorwa Byubuvuziyasuzumye igipimo cyibisubizo bya berberine kubantu bafite umubyibuho ukabije no gushaka gucunga ibiro, asanga dosiye ya miligarama 500 zafashwe inshuro eshatu kumunsi byatumye igabanukaumubiri rusange (BMI)), kuzenguruka mu kibuno n'uburemere bw'umubiri[5].

Ingaruka za Berberine

Dr. McCubbins avuga ko inyongera za Berberine zishobora kugira ingaruka zimwe na zimwe zirimo impiswi, kuribwa mu nda no kubabara umutwe.

Akomeza agira ati: "Berberine igenda ikundwa cyane kandi igurishwa cyane ku baturage bagabanya ibiro". “Witondere kandi ubaze umuganga wa naturopathique ku bijyanye no gukoresha imiti [ya berberine mbere yo kuyikoresha].”

Muganga Zwickey yongeyeho ko mu gihe berberine yihanganira neza, ishobora gutera ububabare bwo mu nda no kwaguka, kuribwa mu nda, impiswi, kuribwa mu nda, isesemi no kuruka.

Berberine ifite umutekano?

Dr. Zwickey avuga ko impungenge z'umutekano wa berberine ari uko ishobora gukorana n'imiti myinshi. Imikoranire ishobora kuba ikomeye cyane ni cyclosporine, imiti ikingira indwara ikoreshwa nyuma yo guterwa urugingo no gufasha gucunga imiterere ya autoimmune nkarubagimpandeasobanura ko berberine yongera ubukana bwa cyclosporine mu maraso.

Hatitawe ku kuba umuntu afata berberine nk'inyongeramusaruro yakuweho cyangwa mu buryo bwose bw'ibyatsi, ni ngombwa gukurikiza amabwiriza yatanzwe yatanzwe n'umusaruro w’ibicuruzwa cyangwa inzobere mu buzima. Dr. Zwickey avuga ko Berberine yanduye ku bana, ndetse n'abantu batwite n'abonsa.

Niki Twakagombye gusuzuma mugihe ugura Berberine?

Dr. Zwickey avuga ko kubera ko abayikora benshi bahanagura berberine ku gihingwa, laboratoire ya gatatu yo gusuzuma laboratoire ya berberine, imbaraga, ubwiza n’ubuziranenge ni ngombwa. Dr. McCubbins yongeyeho ati: "Umuntu agomba kuba umwihariko ku bijyanye no kongera amasoko aturuka mu kigo cy’inyongera cy’umuganga kugira ngo yipimishe ku bandi bantu baturutse mu masosiyete azwi ndetse no kwizeza ubuziranenge ku mabwiriza meza."

Ni ngombwa kandi ko berberine ikomoka ku buryo burambye nk'uko Dr. McCubbins abitangaza. “Goldenseal, nubwo isoko nziza ya berberine, iri mu kaga. Amasosiyete azwi yiyongera azi iki kibazo [”]. Ibirango byinshi byinyongera byerekana mubyatsi bivamo berberine.

Kubera ko berberine idafite ubushakashatsi bwigihe kirekire bwumutekano, umuntu agomba kubanza kubaza abashinzwe ubuzima mbere yo kongeramo berberine muburyo bwabo bwiyongera kugirango barebe ko bikwiye kandi bifite umutekano kubyo bakeneye byihariye byubuzima. Kugira ngo umenye byinshi kubyiza byubuzima bwa berberine, vugana na dogiteri naturopathique, wemejwe ibyatsi cyangwa acupuncturist.